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Sayana® Press (medroxyprogesterone acetate)

What is Sayana Press and what is it used for?

Sayana Press is a contraceptive* injection and a prescription only medicine. It can be used:

  • In women, for long-term contraception; after 2 years, it is recommended to evaluate whether Sayana Press is still the most appropriate option in terms of risks and benefits
  • In female teenagers, but only after all other methods have been discussed with a Healthcare Professional (HCP) and they are considered unsuitable or unacceptable

The active ingredient in Sayana Press is similar to (but not the same as) the natural hormone progesterone that is produced in the ovaries during the second half of the menstrual cycle.  Sayana Press acts by preventing an egg from fully developing and being released from the ovaries during a menstrual cycle.  If an egg is not released, it cannot become fertilised by sperm and result in pregnancy.


Reference Information


*prevents pregnancy


PP-SAY-GBR-0160 / Sept 2018

Pfizer is unable to provide advice on personal medical matters. Please consult your doctor or other relevant health professionals for specific, health-related advice and support.

If you get any side effects when taking this or any other medicine, talk to your doctor or other relevant health professional e.g. pharmacist, nurse.. This includes any possible side effects not listed in the packaging leaflet. You can also report side effects directly via the Yellow Card Scheme at By reporting side effects, you can help provide more information on the safety of this medicine.