What is Dynastat and what is it used for?

Dynastat is used for the short-term treatment of pain in adults after an operation. The active substance in Dynastat, parecoxib, is a ‘prodrug’ of valdecoxib. This means that it is converted to valdecoxib in the body. Valdecoxib is a non‑steroidal anti‑inflammatory drug (NSAID) that belongs to the group of medicines called COX-2 inhibitors (this is short for cyclo-oxygenase-2 inhibitors). Pain and swelling are sometimes caused by substances in the body called prostaglandins. Dynastat works by lowering the amount of these prostaglandins.

As with other medicines in the same group as Dynastat, the risk of heart and blood-vessel problems may increase with higher doses and longer durations of Dynastat treatment. The shortest duration possible and the lowest effective dose of Dynastat should be used.

The medicine can only be obtained with a prescription.

Reference Information

Medicines in Northern Ireland fall under the remit of the European Medicines Agency (EMA) whilst medicines in Great Britain (England, Scotland and Wales) fall under the remit of the Medicines and Healthcare products Regulatory Agency (MHRA) following the UK leaving the European Union. These agencies are responsible for the scientific evaluation, supervision and safety monitoring of medicines developed by pharmaceutical companies.

If you would like to see the Summary of Product Characteristics (SPC) or Patient Information Leaflet (PIL) for Dynastat please follow these links:

Great Britain
Dynastat (parecoxib sodium)

Northern Ireland
Dynastat (parecoxib sodium)

Pfizer is unable to provide advice on personal medical matters. Please consult your doctor or other relevant health professional for specific, health-related advice and support.

If you get any side effects when taking this or any other medicine, talk to your doctor or other relevant health professional e.g. pharmacist, nurse. This includes any possible side effects not listed in the packaging leaflet. You can also report side effects directly via the Yellow Card Scheme at https://yellowcard.mhra.gov.uk or search the Google Play or Apple App Store for MHRA Yellow Card. By reporting side effects, you can help provide more information on the safety of this medicine.